The orphan receptor Nur77 binds cytoplasmic LPS to activate

nuri77Nur77 responds to a wide range of physiological molecules and stimuli. 4, 14 These snals quickly induce Nur77 expression and stimulate its transcriptional activity; Nur77The role of Nur77 in celastrol-induced mitophagy was illustrated by reduction of autophagic mitochondria (from 12.20 to 0.02%) and diminished COXII degradation in HeLa